An antenna structure includes a first feeding source, a second feeding source, and a ring-shaped frame. The ring-shaped frame defines a first radiating portion and a second radiating portion. A current signal flows from the first feeding source to the first radiating portion, the first radiating portion activates a first resonance mode and a second resonance mode simultaneously to generate radiation signals in a first frequency band and a second frequency band. A current signal flows from the second feeding source to the second radiating portion, the second radiating portion activates a third resonance mode and a fourth resonance mode simultaneously to generate radiation signals in a third frequency band and a fourth frequency band. A wireless communication device is also provided.