In an embodiment, a resettable shield-activated injection training device is provided. The training device includes an outer housing comprising a proximal end and a distal end, an inner housing comprising a proximal end and a distal end, plunger retention protrusions near the proximal end, and an asymmetrical projection at the distal end. The training device may further include a safety shield slidable relative to the outer housing between an extended position and a retracted position, a plunger slidable relative to the outer housing, the plunger comprising one or more plunger rail portions, and a rotatable reset component having axial and radial movement, the reset component comprising a proximal end, a distal end, an outer circumference, and an inner circumference, a notched portion, a plunger rail interface, and an asymmetrical ramped portion in the inner circumference, and a safety shield locking tab near the proximal end of the reset component configured to interact with the safety shield to lock the safety shield in an extended position. The training device may further include a reset spring associated with the rotatable reset component, wherein an interaction between the asymmetrical projection and the asymmetrical ramped portion of the reset component causes rotational and axial movement of the reset component toward the proximal end of the outer housing, loads the reset spring, and releases the contact between the safety shield locking tab and the safety shield to unlock the safety shield and reset the device.