In case of network isolation of a host executing one or more virtual machines, the state of the one of more virtual machines is saved using a variety of isolation response mechanisms. Isolation responses may include a live migration to another host using a shared storage system connected to both hosts, a virtual machine suspend and resume operation, and a snapshot reversion operation. The execution state of the virtual machine(s) running on the isolated host, which includes the state of the guest operating system and any running applications, are maintained in the other host, even after host isolation has occurred.