Front-end system having switchable amplifier output stage. In some embodiments, a method for operating a front-end system can include amplifying a signal in a driver stage of a power amplifier, and routing the signal from the driver stage to a selected one of a plurality of output stages, such that the selected output stage further amplifies the signal. The method can further include routing the amplified signal for transmission from the selected output stage to a selected one of a plurality of antennas.