Automatic mapping of semantics in healthcare is provided. Data sets have different semantics (e.g., Gender designated with M and F in one system and Sex designated with 1 or 2 in another system). For semantic interoperability, the semantic links between the semantic systems of different healthcare entities are created (e.g., Gender=Sex and/or 1=F and 2=M) by a processor from statistics of the data itself. The distribution of variables, values, or variables and values, with or without other information and/or logic, is used to create a map from one semantic system to another. Similar distributions of other variable and/or values are likely to be for variables and/or values with the same meaning.