Systems and methods for isolating audio content and biometric authentication include receiving, with an audio receiver, an audio signal spanning a plurality of frequency bands, identifying a speech signal carried by a voice frequency band selected from the plurality of frequency bands, enhancing the speech signal relative to other audio content within the audio signal, and extracting a voice profile key that uniquely identifies the speech signal, wherein enhancing the first speech signal comprises adjusting attack and release times of the speech signal based on sound events within the speech signal, the attack time being associated with very high frequency sounds that are not phase-shifted.