A communication system provides connection, configuration, and control of a musical instrument. A musical instrument includes a first communication link disposed on the musical instrument. Various music related accessories, such as a speaker, effects pedal, computer, mobile communication device, and synthesizer, includes a second communication link. A communication link transmits and receives the audio signal and control data between the musical instrument and accessories through the first and second communication links. A controller receives the audio signal and control data for configuring and controlling the device. The communication link is further connected to a computer, mobile communication device, and server through a communication network. A web server interface is coupled to the communication link for user selection and viewing of the control data in human perceive form. A user control interface with one or more webpages is connected to the communication link for configuring the musical instrument and accessories.