Systems, methods, and media for presenting panel-based electronic documents are provided. In accordance with some embodiments, systems for presenting panel-based electronic documents are provided, the system comprising: at least one processor programmed to: receive an electronic document, a definition of a first panel on a page in the electronic document, and a definition of a second panel on the page in the electronic document; control a display of the first panel based on the definition of the first panel; and transition from the display of the first panel to a display of the second panel by re-scaling the display and panning from the first panel to the second panel.