A Mura compensation circuit and method, a driving circuit and a display device are provided. The Mura compensation circuit comprises: a vertical Mura compensation unit, for providing a corresponding gamma voltage to a vertical block Mura region and a vertical non-Mura region of a display panel respectively, to compensate for a vertical Mura phenomenon; and/or a horizontal Mura compensation unit, for providing a corresponding gate drive signal and/or a corresponding charging/discharging control signal to a horizontal block Mura region and a horizontal non-Mura region of a display panel respectively, to compensate for a horizontal Mura phenomenon. The Mura compensation circuit can make the different regions of the display panel have the same display effect, and improve reduction of display quality caused by impedance difference at different positions of the display panel, thereby raising the quality of a picture, and can be promoted and applied widely.