A robust segmentation technique based on multi-layer classification technique to identify the lesion boundary is described. The inventors have discovered a technique based on training several classifiers such that to classify each pixel as lesion versus normal Each classifier is trained on a specific range of image resolutions. Then, for a new test image, the trained classifiers are applied on the image. Then by fusing the prediction results in pixel level a probability map is generated. In the next step, a thresholding method is applied to convert the probability map to a binary mask, which determines a mole border.