Invention Grant
- Patent Title: Structure-based peptide inhibitors of P53 aggregation as a new approach to cancer therapeutics
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Application No.: US15877134Application Date: 2018-01-22
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Publication No.: US10400010B2Publication Date: 2019-09-03
- Inventor: David S. Eisenberg , Alice Soragni , Lin Jiang
- Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Applicant Address: US CA Oakland
- Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee Address: US CA Oakland
- Agency: Gates & Cooper LLP
- Main IPC: C07K7/06
- IPC: C07K7/06 ; G16B15/00 ; G16B20/00 ; C07K14/47 ; A61K38/00
Abstract:
This invention relates, e.g., to an inhibitory peptide or CPP inhibitor which specifically binds to p53 having an aberrant conformation (e.g., is aggregated or misfolded) and inhibits p53 amyloidogenic aggregation or restores proper folding of the misfolded protein. Methods of using the inhibitory peptide or CPP inhibitor (e.g. to treat subjects having tumors that comprise aggregated p53) are described.
Public/Granted literature
- US20180155396A1 STRUCTURE-BASED PEPTIDE INHIBITORS OF P53 AGGREGATION AS A NEW APPROACH TO CANCER THERAPEUTICS Public/Granted day:2018-06-07
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