Invention Grant
- Patent Title: Benzopiperidine derivative, preparation method thereof and medical use thereof
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Application No.: US16061676Application Date: 2016-12-02
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Publication No.: US10398689B2Publication Date: 2019-09-03
- Inventor: Fanglong Yang , Ling Zhang , Chunfei Wang , Mingxun He , Qiyue Hu , Feng He , Weikang Tao , Piaoyang Sun
- Applicant: Jiangsu Hengrui Medicine Co., Ltd. , Shanghai Hengrui Pharmaceutical Co., Ltd.
- Applicant Address: CN Lianyungang, Jiangsu CN Shanghai
- Assignee: Jiangsu Hengrui Medicine Co., Ltd.,Shanghai Hengrui Pharmaceutical Co., Ltd.
- Current Assignee: Jiangsu Hengrui Medicine Co., Ltd.,Shanghai Hengrui Pharmaceutical Co., Ltd.
- Current Assignee Address: CN Lianyungang, Jiangsu CN Shanghai
- Agency: Panitch Schwarze Belisario & Nadel LLP
- Priority: CN201510975923 20151222
- International Application: PCT/CN2016/108367 WO 20161202
- International Announcement: WO2017/107754 WO 20170629
- Main IPC: A61K31/4725
- IPC: A61K31/4725 ; C07D401/04 ; A61P35/00
Abstract:
The present invention relates to a benzopiperidine derivative, a preparation method thereof and a medical use thereof. In particular, the present invention relates to a benzopiperidine derivative as shown by general formula (I), a preparation method thereof and a pharmaceutical composition containing the derivative, as well as a use thereof as an estrogen receptor modulator in the prevention and/or treatment of estrogen receptor-mediated or dependent diseases or conditions. Preferably, the disease is breast cancer. The substituents in the general formula (I) are the same as those defined in the description.
Public/Granted literature
- US20180318284A1 BENZOPIPERIDINE DERIVATIVE, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF Public/Granted day:2018-11-08
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