Approaches presented herein enable dynamic security policies through a plurality of application profiles. More specifically, a mobile device can open a profile of a plurality of profiles, each associated with an unlock credential and a security scope, in response to an unlock credential associated with that profile. All these profiles can be opened in a single user session and can be swapped within the session in response to an unlock credential corresponding to the desired profile. When the mobile device receives a request to open a digital item, the digital item is compared to a security scope of the opened profile to determine whether access to the digital item is permitted, and, in response to the determination, access to the digital item is permitted or denied. A list of digital items permitted to be accessed in each profile can be synchronized to a list received from a mobile device manager.