A storage-media-agnostic chassis apparatus may include a media-agnostic storage bay that (1) is adapted to house media storage devices of a plurality of different media storage device types with different physical dimensions, (2) is reconfigurable via removing at least one media storage device of a media storage device type from the media-agnostic storage bay and inserting at least one media storage device of an additional media storage device type, (3) is dimensioned to simultaneously store a plurality of media storage devices, and (4) comprises a plurality of connectors adapted to simultaneously connect to the media storage devices. The apparatus may also include a storage controller card, a compute module that is separate from but removably attached to the media-agnostic storage bay, and a backplane that facilitates communication between the media storage device and the compute module. Various other methods, systems, and apparatuses are also disclosed.