The present disclosure provides a system and a method for producing deuterium depleted water. The system includes a chlor-alkali electrolysis cell, a compressor, a cooling water scrubber tower, a hydrogen combustor, a boiler, a cooling condensation apparatus, a crude deuterium depleted water storage tank, a water purification apparatus and a water filling machinery. The method includes: generating hydrogen from a chlor-alkali electrolysis of salt water in the chlor-alkali electrolysis cell; increasing the pressure of the generated hydrogen; purifying and cryogenically cooling the generated hydrogen; combusting the mixture of hydrogen and oxygen to generate water steam; condensing the water steam to produce the crude deuterium depleted water in the cooling condensation apparatus; storing the produced crude deuterium depleted water in the crude deuterium depleted water storage tank; purifying the produced crude deuterium depleted water through the water purification apparatus; packaging the purified deuterium depleted water with the water filling machinery.