A rinse monitoring and control system for a self-propelled sprayer is configured to allow automatic rinsing of plumbing components and tubing of the sprayer with a liquid rinse by automatically controlling the timing and sequencing of electronic valves upon receiving a rinse command. Aspects of the rinsing can be configured by an operator, such as the whether the product tank is rinsed, the duration of each rinse, and the number of rinse cycles. The valves and liquid flow can be monitored in real time from a touchscreen HMI during the rinsing. Accordingly, the sprayer can be thoroughly rinsed by pressing a single button to generate the rinse command, without requiring the operator to manually actuate valves and/or recall stages of the rinse sequence.