A server with an airflow guiding structure includes a chassis having a storage area, a computing area and a fan module installed between the storage area and the computing area. The storage area includes multiple storage modules, and the computing area includes a fan module and a motherboard electrically coupled to each storage module. The fan module has an air inlet configured to be corresponding to the storage area, an air outlet configured to be corresponsive to the computing area and an airflow guiding component with multiple airflow guiding ducts. The airflow guiding component is configured to be corresponsive to the air inlet. Therefore, the vibration of the fan module is reduced and the operation efficiency of the storage medium and the service life of the server are improved.