A mouse with a removable button switch includes: a release unit, including a bearer mounted on a circuit board of the mouse; a press-fixing and ejection means provided with a press-fixing part and an ejection part; and a press-fixing means, the press-fixing means and the press-fixing and ejection means being oppositely disposed on both sides of the bearer, and the press-fixing means being provided with the press-fixing part. In the mouse with the removable button switch in the present invention, because the button switch is not fixed on the circuit board of the mouse in a welding manner, when the button switch is faulty or a different hand feeling is required, the button switch can be conveniently replaced without causing damage to the mouse.