Invention Grant
- Patent Title: Crystal form B of ribociclib succinate
-
Application No.: US16054443Application Date: 2018-08-03
-
Publication No.: US10336763B1Publication Date: 2019-07-02
- Inventor: Satyanarayana Kamani , Tzu-Chiang Lu , Hsin-Yun Chang , Chin-Cheng Mai
- Applicant: Chunghwa Chemical Synthesis & Biotech Co. Ltd.
- Applicant Address: TW New Taipei
- Assignee: CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO. LTD.
- Current Assignee: CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO. LTD.
- Current Assignee Address: TW New Taipei
- Agency: Muncy, Geissler, Olds & Lowe, P.C.
- Priority: TW107116819A 20180517
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D487/04 ; A61P35/04

Abstract:
The present invention relates to crystal forms B, C and D of Ribociclib succinate salt and derivatives thereof, and their preparation method and composition. The crystal forms B, C and D of Ribociclib succinate salts are obtained by adding 7-cyclopentyl-N,N-dimethyl-2-(5-(piperain-1-yl)pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide solution into succinic acid solution for reaction, stirring the solution under high temperature, filtering the solution after cooling off.
Information query
IPC分类: