Invention Grant
- Patent Title: Fused pyrazole derivatives, preparation method thereof, and use thereof in treatment of cancers, inflammation and immune diseases
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Application No.: US16073607Application Date: 2016-12-28
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Publication No.: US10336755B2Publication Date: 2019-07-02
- Inventor: Xiangyang Chen , Yucheng Pang
- Applicant: Beijing InnoCare Pharma Tech Co., Ltd.
- Applicant Address: CN Beijing
- Assignee: Beijing Innocare Pharma Tech Co., Ltd.
- Current Assignee: Beijing Innocare Pharma Tech Co., Ltd.
- Current Assignee Address: CN Beijing
- Agency: Fox Rothschild LLP
- Priority: CN201610066886 20160129
- International Application: PCT/CN2016/112625 WO 20161228
- International Announcement: WO2017/128917 WO 20170803
- Main IPC: C07D471/06
- IPC: C07D471/06 ; A61K31/437 ; C07D471/22 ; A61K31/519 ; C07D471/04 ; C07D487/04 ; A61P37/00 ; A61P35/00 ; C07D401/04 ; C07D401/14

Abstract:
The present invention relates to pyrazole fused-ring derivatives, their preparation methods, and use thereof in medicine. In particular, the present invention relates to a novel derivative represented by formula (I), and a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising the same and a method for preparing the same. The present invention also relates to use of the derivatives and the pharmaceutically acceptable salt thereof or the pharmaceutical composition comprising the same in the preparation of therapeutic agents, in particular Bruton tyrosine kinase inhibitors, and preparing a medicament for treating and/or preventing tumors and inflammatory associated diseases. The substituents on formula (I) are defined same as in the specification.
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