Invention Grant
- Patent Title: Carbocyclic compounds as ROR gamma modulators
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Application No.: US16204977Application Date: 2018-11-29
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Publication No.: US10336688B2Publication Date: 2019-07-02
- Inventor: Sanjib Das , Laxmikant A. Gharat , Rajendra L. Harde , Dnyaneshwar E. Shelke , Shailesh R. Pardeshi , Abraham Thomas , Neelima Khairatkar-Joshi , Daisy M. Shah , Malini Bajpai
- Applicant: Glenmark Pharmaceuticals S.A.
- Applicant Address: CH La Chaux-de-Fonds
- Assignee: GLENMARK PHARMACEUTICALS S.A.
- Current Assignee: GLENMARK PHARMACEUTICALS S.A.
- Current Assignee Address: CH La Chaux-de-Fonds
- Agency: Blank Rome LLP
- Priority: IN3299/MUM/2015 20150828
- Main IPC: C07C237/42
- IPC: C07C237/42 ; A61P11/14 ; A61P11/08 ; A61P17/06 ; A61P11/06

Abstract:
The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
Public/Granted literature
- US20190144375A1 NOVEL CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS Public/Granted day:2019-05-16
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