The application provides an ink cartridge chip, an ink cartridge and an operation method for giving response to printing work, and belongs to the technical field of printing. The ink cartridge chip comprises a storage module at least provided with a first ink quantity data block and a second ink quantity data block which share data with a printer and make the printer have one printing mode, wherein the first ink quantity data block is fixed in the printing mode, and the second ink quantity data block is variable in the printing mode. The ink cartridge comprises the ink cartridge chip. The application with a printing system is easy, convenient and fast, universality is high, printing at a high ink utilization rate is achieved in one printing mode, and the problems of resource waste, consumable loss, high cost and the like are solved.