Methods and devices are provided having a locking mechanism configured to selectively prevent actuation of the surgical device, e.g., opening and closing of jaws at a distal end of the device, moving a cutting element of the device, etc. In an exemplary embodiment, a device is provided having a closure lever actuator that can move between an open position and an actuated position, thereby opening and closing, respectively, jaws at the distal end of the device. In addition, the device can include a knife trigger that is configured to move a cutting element through the jaws. The device can further include a knife lockout feature that can prevent actuation of the knife trigger until the closure lever is in the actuated position.