Systems and methods are disclosed that may provide for selective multi-user uplink (UL) of data for wireless devices. For example, a first wireless device may request permission to initiate a UL transmission to a second wireless device. The first wireless device may then receive, from the second wireless device, permission to initiate the UL transmission according to a multi-user (MU) UL protocol, determine a threshold duration for the UL transmission, and transmit UL data to the second wireless device according to the MU UL protocol and the threshold duration.