The disclosed computer-implemented method for dynamically validating remote requests within enterprise networks may include (1) receiving, on a target system within an enterprise network, a request to access a portion of the target system from a remote system within the enterprise network, (2) performing a validation operation to determine whether the remote system is trustworthy to access the portion of the target system by (A) querying an enterprise security system to authorize the request from the remote system and (B) receiving, from the enterprise security system in response to the query, a notification indicating whether the remote system is trustworthy to access the portion of the target system, and then (3) determining whether to grant the request based at least in part on the notification received from the enterprise security system as part of the validation operation. Various other methods, systems, and computer-readable media are also disclosed.