Systems and methods for unmanned vehicle security and control are provided herein. An exemplary system includes a control station and an unmanned vehicle. The unmanned vehicle may be locked from remote control by the control station. The system may also include a first access control hardware device attached to the control station and communicably coupled, using a network, with the unmanned vehicle. The system may also include a second access control hardware device physically attached to the unmanned vehicle and communicably coupled, using the network, with the control station. The first and/or second access control hardware devices are utilized to unlock the unmanned vehicle from remote control by the control station.