Structures and techniques, using superconducting Josephson-junction based circuits, to directly engineer physical multiqubit (or “many-qubit”) interactions in a non-perturbative manner. In one embodiment, a system for multiqubit interaction includes: a multispin coupler including a plurality of loops, each loop having a pair of Josephson junctions; and a plurality of qubits each inductively coupled to the multispin coupler.