An arrangement and corresponding method are described for multi-domain natural language processing. Multiple parallel domain pipelines are used for processing a natural language input. Each domain pipeline represents a different specific subject domain of related concepts. Each domain pipeline includes a mention module that processes the natural language input using natural language understanding (NLU) to determine a corresponding list of mentions, and an interpretation generator that receives the list of mentions and produces a rank-ordered domain output set of sentence-level interpretation candidates. A global evidence ranker receives the domain output sets from the domain pipelines and produces an overall rank-ordered final output set of sentence-level interpretations.