Invention Grant
- Patent Title: Methods, systems, and reagents for direct RNA sequencing
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Application No.: US15334935Application Date: 2016-10-26
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Publication No.: US10280411B2Publication Date: 2019-05-07
- Inventor: Satwik Kamtekar , Jeremiah Hanes , Erik Miller
- Applicant: Pacific Biosciences of California, Inc.
- Applicant Address: US CA Menlo Park
- Assignee: Pacific Biosciences of California, In.c
- Current Assignee: Pacific Biosciences of California, In.c
- Current Assignee Address: US CA Menlo Park
- Agent Monicia Elrod-Erickson
- Main IPC: C12N9/12
- IPC: C12N9/12 ; C12Q1/6869 ; C12M1/42 ; C12P19/34
Abstract:
Provided are compositions comprising recombinant polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for sequencing RNA or RNA/DNA templates. Polymerases that topologically encircle the template nucleic acid are provided. Also provided are methods of using such polymerases to make a DNA or to sequence a template comprising RNA.
Public/Granted literature
- US20170159033A1 METHODS, SYSTEMS, AND REAGENTS FOR DIRECT RNA SEQUENCING Public/Granted day:2017-06-08
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