Invention Grant
- Patent Title: System to deliver adaptive epidural and/or subdural electrical spinal cord stimulation to facilitate and restore locomotion after a neuromotor impairment
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Application No.: US15717738Application Date: 2017-09-27
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Publication No.: US10279167B2Publication Date: 2019-05-07
- Inventor: Grégoire Courtine , Nikolaus Wenger , Eduardo Martin Moraud , Silvestro Micera , Marco Bonizzato
- Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
- Applicant Address: CH Lausanne
- Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)
- Current Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)
- Current Assignee Address: CH Lausanne
- Agency: McCoy Russell LLP
- Priority: EP13191003 20131031
- Main IPC: A61N1/05
- IPC: A61N1/05 ; A61B5/11 ; A61N1/36 ; A61B5/04 ; A61B5/0488 ; A61B5/0476 ; A61B5/00

Abstract:
The present disclosure provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising electrodes for applying to a subject neuromodulation with adjustable stimulation parameters, the electrodes being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with the electrodes said and providing the electrodes with new stimulation parameters, with minimum delay. The system of the disclosure improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), a multiple input-single output (MISO) model, or a multiple input-multiple output (MIMO) model.
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