Systems, methods, and computer program products for classifying a brain are disclosed. An embodiment method includes processing image data to generate segmented image data of a brain cortex. The method further includes generating a statistical analysis of the brain based on a three dimensional (3D) model of the brain cortex generated from the segmented image data. The method further includes using the statistical analysis to classify the brain cortex and to identify the brain as being associated with a particular neurological condition. According to a further embodiment, generating the 3D model of the brain further includes registering a 3D volume associated with the model with a corresponding reference volume and generating a 3D mesh associated with the registered 3D volume. The method further includes generating the statistical analysis by analyzing individual mesh nodes of the registered 3D mesh based on a spherical harmonic shape analysis of the 3D model.