The present disclosure provides a method and a device of driving a display and a display device. The method includes: conducting first image data combined with image data relevant to the first image data in time/space by a micro disturbance operation processing, to obtain second image data; and outputting the second image data. By changing the conventional driving mechanism, conducting the first image data combined with relevant image data with respect to a time axis by an operation processing, for example, adding a time axis correction parameter which may be dynamically adjusted and conducting a micro disturbance operation, so as to determine color gray scales of respective sub-pixels on the display according to an adjusted driving circuit, which may make colors of image data on the display more plentiful and optimize display effect.