Embodiments of waste containment apparatuses and methods are provided herein for receiving, analyzing, verifying and disposing of a controlled substance (CS) waste dose. One embodiment of a waste containment apparatus includes a plurality of single-dose containers, each having an inlet port for receiving a CS waste dose deposited within the single-dose container, an analysis chamber for reserving a fixed amount of the received CS waste dose for analysis, and a storage chamber for storing a remaining portion of the received CS waste dose. The waste containment apparatus includes further components for measuring a volume and determining a composition and concentration of the CS waste dose deposited within the single-dose container, and verifying the CS waste dose deposited within the single-dose container if the volume, composition and concentration of the CS waste matches information about the CS waste dose received from a depositor of the CS waste dose.