The various embodiments described below are directed to providing authenticated and confidential messaging from software executing on a host (e.g. a secure software application or security kernel) to and from I/O devices operating on a USB bus. The embodiments can protect against attacks that are levied by software executing on a host computer. In some embodiments, a secure functional component or module is provided and can use encryption techniques to provide protection against observation and manipulation of USB data. In other embodiments, USB data can be protected through techniques that do not utilized (or are not required to utilize) encryption techniques. In accordance with these embodiments, USB devices can be designated as “secure” and, hence, data sent over the USB to and from such designated devices can be provided into protected memory. Memory indirection techniques can be utilized to ensure that data to and from secure devices is protected.