Invention Grant
- Patent Title: Potassium channel blockers and use thereof in the treatment of autoimmune diseases
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Application No.: US15503841Application Date: 2015-08-14
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Publication No.: US10246496B2Publication Date: 2019-04-02
- Inventor: Raymond S. Norton , Shih Chieh Chang , Michael W. Pennington , Christine Beeton , Brian J. Smith
- Applicant: MONASH UNIVERSITY , LA TROBE UNIVERSITY , PEPTIDES INTERNATIONAL, INC. , BAYLOR COLLEGE OF MEDICINE
- Applicant Address: AU AU US TX Houston US KY Louisville
- Assignee: LA TROBE UNIVERSITY,MONASH UNIVERSITY,BAYLOR COLLEGE OF MEDICINE,PEPTIDES INTERNATIONAL, INC.
- Current Assignee: LA TROBE UNIVERSITY,MONASH UNIVERSITY,BAYLOR COLLEGE OF MEDICINE,PEPTIDES INTERNATIONAL, INC.
- Current Assignee Address: AU AU US TX Houston US KY Louisville
- Agency: Sheridan Ross P.C.
- Priority: AU2014903189 20140815
- International Application: PCT/AU2015/000487 WO 20150814
- International Announcement: WO2016/023072 WO 20160218
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/17 ; C07K14/435 ; C12N15/63 ; C07K4/00 ; C07K19/00
Abstract:
Novel analogues of the sea anemone Stichodactyla helianthus toxin ShK, and their use as, for example, therapeutic agents for treating autoimmune diseases are disclosed. The analogues comprise a ShK toxin polypeptide and an N-terminal extension comprising an amino acid sequence according to formula (I): wherein X−4 is D, E or other negatively-charged amino acid or derivative thereof, X−3 is E, I, L, S, V, W or a tryptophan derivative, X−2 is any amino acid, X−1 is any amino acid, a is absent or a first additional moiety, and b is absent or a second additional moiety. a-X−4X−3X−2X−1-b(SEQ ID NO: 3) (I)
Public/Granted literature
- US20170362286A1 NOVEL POTASSIUM CHANNEL BLOCKERS AND USE THEREOF IN THE TREATMENT OF AUTOIMMUNE DISEASES Public/Granted day:2017-12-21
Information query
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