Invention Grant
- Patent Title: Dosage form compositions comprising an inhibitor of bruton's tyrosine kinase
-
Application No.: US15442774Application Date: 2017-02-27
-
Publication No.: US10246461B2Publication Date: 2019-04-02
- Inventor: Chen Mao , Dawen Kou , Po-Chang Chiang
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Armstrong Teasdale LLP
- Main IPC: A61K31/498
- IPC: A61K31/498 ; A61K47/12 ; A61K9/20 ; C07D487/04 ; C07C309/04 ; A61K9/14 ; A61K31/4985

Abstract:
The invention relates generally to pharmaceutical tablet compositions comprising fumaric acid and the compound (S)-2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-2,3,4,6,7,8-hexahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one free base that is an inhibitor of Bruton's tyrosine kinase. The invention further relates to amorphous solid dispersions comprising at least one polymer and the Bruton's kinase inhibitor free base compound. The invention further relates to crystalline mesylate salts, crystalline chloride salts and crystalline sulfate salts of the Bruton's kinase inhibitor free base compound. In some aspects, the crystalline salts are single polymorphs.
Public/Granted literature
- US20180251462A2 DOSAGE FORM COMPOSITIONS COMPRISING AN INHIBITOR OF BRUTON'S TYROSINE KINASE Public/Granted day:2018-09-06
Information query
IPC分类: