Invention Grant
![Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[E]azulene and crytalline forms thereof](/docs/US/2019-04-02/US10246460B2/abs.jpg.600x600.jpg)
- Patent Title: Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[E]azulene and crytalline forms thereof
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Application No.: US15172542Application Date: 2016-06-03
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Publication No.: US10246460B2Publication Date: 2019-04-02
- Inventor: Benno Rothenhaeusler , Rene Trussardi , Fabienne Hoffmann-Emery , Urs Schwitter , Jean-Michel Adam , Olaf Grassmann , Thomas Hartung , Frederic Ran , Ralph Diodone , Christophe Pfleger , Bjorn Bartels
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Little Falls
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Little Falls
- Agent Robert C. Hall
- Priority: EP13195864 20131205
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D243/14
![Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[E]azulene and crytalline forms thereof](/abs-image/US/2019/04/02/US10246460B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
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