A stereotactic surgical instrument for use in stereotactical therapy and surgery and a coupling mechanism for such an instrument is disclosed. The stereotactic surgical instrument includes a semi-circular arc part and a head frame. The head frame is arranged for fixation to a head of a patient by pins or screws. The arc part includes coupling members shaped as rings arranged at a fixed distance from each other for attaching and locking the arc part to the head frame. The head frame includes support members formed as rings for receiving corresponding coupling members. Each coupling member includes a pivotable clamp element arranged to partly surround a respective support member circumferentially when the arc part is coupled to the head frame. The coupling members include locking elements arranged to receive a tip portion of the respective clamp element and adjustable locking knobs for tightening and locking respective coupling member to respective support member.