Disclosed is a data compression method of DeMura Table, a data decompression method of DeMura Table, and a Mura compensation method. The data compression method includes: acquiring image information of a display panel and obtaining an original DeMura Table; performing region extraction based on the original DeMura Table; performing edge detection based on the Mura region obtained from extraction; distributing each sub-pixel element included in the display panel as per results from the region extraction and the edge detection to determine a numerical value of each sampling point in the DeMura Table. The method may save storage costs of DeMura Table.