A method of processing a frame in a data processing system is provided, in which the frame comprises one or more frame regions that together form the frame, and each frame region is represented as one or more data values, with each data value being represented by a set of data. The method comprises, for at least one region of the frame, when a memory access operation is to be performed for the region of the frame, comparing (163) a portion of the data representing data values for the frame region (165) with a corresponding portion of the data representing the corresponding data values for a previous frame region (162), which is a frame region for which the memory access operation has been performed, to determine if the portion of the data representing the data values for the frame region is similar to the corresponding portion of the data representing the data values for the previous frame region, wherein the portion of the data representing the data values for a frame region comprises a sub-set of controller data (167a, 167b) from each set of data representing a data value of the data values for the frame region. In an embodiment, if the portion of the data representing the data values for the frame region is determined to be similar to the corresponding portion of the data representing the data values for the previous frame region, the memory access operation is omitted, or, if the portion of the data representing the data values for the frame region is determined not to be similar to the corresponding portion of the data representing the data values for the previous frame region, the memory access operation is performed (169).