Invention Grant
- Patent Title: Generation of pancreatic endoderm from pluripotent stem cells using small molecules
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Application No.: US15215807Application Date: 2016-07-21
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Publication No.: US10221392B2Publication Date: 2019-03-05
- Inventor: Jenny Ekberg , Mattias Hansson , Ulrik Doehn , Katja Hess , Nina Funa
- Applicant: Novo Nordisk A/S , Takara Bio Europe AB
- Applicant Address: DK Bagsværd SE Gothenburg
- Assignee: Novo Nordisk A/S,TAKARA BIO EUROPE AB
- Current Assignee: Novo Nordisk A/S,TAKARA BIO EUROPE AB
- Current Assignee Address: DK Bagsværd SE Gothenburg
- Agent Leon Y. Lum
- Priority: EP12182747 20120903; EP12198820 20121221
- Main IPC: C12N5/071
- IPC: C12N5/071
Abstract:
A method of producing pancreatic cells or pancreatic cell precursors expressing at least 5% PDX1/NKX6.1 double positive, comprising exposing definitive endoderm cells to an effective amount of one or more small molecules, to differentiate the human definitive endoderm cells into the pancreatic cells or pancreatic cell precursors. The present invention also relates to pancreatic endoderm cells produced by said methods and uses of said pancreatic endoderm cells.
Public/Granted literature
- US20160326495A1 Generation of Pancreatic Endoderm from Pluripotent Stem Cells using Small Molecules Public/Granted day:2016-11-10
Information query
