Invention Grant
- Patent Title: Engineered outer domain (eOD) of HIV gp120 and mutants thereof
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Application No.: US14978132Application Date: 2015-12-22
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Publication No.: US10221217B2Publication Date: 2019-03-05
- Inventor: Po-Ssu Huang , Joseph Graham Jardine , Sergey V. Menis , William Ray Schief , Neil P. King
- Applicant: University of Washington, Center For Commercialization , The Scripps Research Institute , International AIDS Vaccine Initiative
- Applicant Address: US WA Seattle US CA La Jolla US NY New York
- Assignee: University of Washington, Center for Commercialization,The Scripps Research Institute,International AIDS Vaccine Initiative
- Current Assignee: University of Washington, Center for Commercialization,The Scripps Research Institute,International AIDS Vaccine Initiative
- Current Assignee Address: US WA Seattle US CA La Jolla US NY New York
- Agency: Duane Morris LLP
- Agent Thomas J. Kowalski; Deborah L. Lu
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/21 ; A61K39/12 ; C07K14/005 ; C07K16/10 ; A61K38/00 ; G01N33/564
Abstract:
The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.
Public/Granted literature
- US20160185825A1 ENGINEERED OUTER DOMAIN (EOD) OF HIV GP120 AND MUTANTS THEREOF Public/Granted day:2016-06-30
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