Invention Grant
- Patent Title: Methods for controlled proliferation of stem cells / generating inner ear hair cells using 3-(pyridin-2-yl)-1H-indol-2-ol based compounds
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Application No.: US15949780Application Date: 2018-04-10
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Publication No.: US10220041B2Publication Date: 2019-03-05
- Inventor: Christopher Loose , Will McLean , Melissa Hill-Drzewi
- Applicant: Frequency Therapeutics, Inc.
- Applicant Address: US MA Woburn
- Assignee: Frequency Therapeutics, Inc.
- Current Assignee: Frequency Therapeutics, Inc.
- Current Assignee Address: US MA Woburn
- Agency: Cooley LLP
- Agent J. Dean Farmer; Xixi Sun
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/4439 ; A61K9/00
Abstract:
The present invention relates to methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells. Specifically, the invention relates to methods of using compounds comprising a 3-(pyridin-2-yl)-1H-indol-2-ol containing moiety having a Formula I: and pharmaceutically acceptable salts thereof.
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