Invention Grant
- Patent Title: 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2 receptors
-
Application No.: US15500234Application Date: 2015-07-30
-
Publication No.: US10220032B2Publication Date: 2019-03-05
- Inventor: Susana Conde-Ceide , Michiel Luc Maria Van Gool , María Luz Martín-Martín
- Applicant: Janssen Pharmaceutica NV
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Priority: EP14179601 20140801
- International Application: PCT/EP2015/067534 WO 20150730
- International Announcement: WO2016/016382 WO 20160204
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/4985 ; C07D231/54 ; C07D261/08
![6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2 receptors](/abs-image/US/2019/03/05/US10220032B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor sub-type 2 (“mGluR2”) of Formula I: The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such com-pounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.
Public/Granted literature
Information query