This disclosure relates generally to screening candidate profile, and more particularly to system and method for screening candidate profile. In one embodiment, the method includes dividing a candidate profile into a plurality of subset-profiles having subset-profile information of attributes of the candidate profile. The subset-profile information is mapped with target-profile information of a plurality of targets to identify a set of targets capable of screening the subset-profile information. Queries are provisioned to the set of targets for performing screening, and responses to queries are received from therefrom. An aggregated weightage associated with the responses is computed based at least on an extent of matching of the responses and a confidence score associated with each target of the set of targets. The aggregated weightage is compared with a threshold value of weightage to identify the subset-profile information as one of a valid information and an invalid information.