Invention Grant
- Patent Title: Hexuronate C4-epimerase mutant with improved conversion activity, and method for producing D-tagatose by using same
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Application No.: US15748164Application Date: 2016-07-29
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Publication No.: US10196626B2Publication Date: 2019-02-05
- Inventor: Sung Jae Yang , Yang Hee Kim , Il Hyang Park , Young Mi Lee , Hyun Kug Cho , Seong Bo Kim , Seung Won Park
- Applicant: CJ CHEILJEDANG CORPORATION
- Applicant Address: KR Seoul
- Assignee: CJ CHEILJEDANG CORPORATION
- Current Assignee: CJ CHEILJEDANG CORPORATION
- Current Assignee Address: KR Seoul
- Agency: Knobbe Martens Olson & Bear LLP
- Priority: KR10-2015-0107436 20150729
- International Application: PCT/KR2016/008412 WO 20160729
- International Announcement: WO2017/018863 WO 20170202
- Main IPC: C12N9/90
- IPC: C12N9/90 ; C12P19/02 ; C12N1/20 ; C12P19/24 ; C12R1/19
Abstract:
A hexuronate C4-epimerase with improved conversion activity and a method for producing D-tagatose using the hexuronate C4-epimerase. The hexuronate C4-epimerase includes an amino acid sequence set forth in SEQ ID NO: 1, in which serine (S) at position 125, serine (S) at position 185, valine (V) at position 267, serine (S) at position 268, threonine (T) at position 272, tryptophan (W) at position 306, arginine (R) at position 386 and tyrosine (Y) at position 403 from an N-terminal of hexunorate C4-epimerase are mutated.
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