The control circuit for a DC-DC converter includes a differential amplifier and an oscillator, and also a multiplier and a voltage divider circuit. The multiplier has a first input terminal receiving a feedback voltage derived from an output voltage of the DC-DC converter through the voltage divider circuit, a second input terminal receiving a parameter compensation value, and an output terminal connected to a first input terminal of the differential amplifier. A second input terminal of the differential amplifier receives a reference voltage. The differential amplifier provides a differential signal to the oscillator. The oscillator is connected to a switch driver module of the DC-DC converter so as to provide an output signal whose frequency is proportional to the differential signal. The control circuit is able to effectively reduce response time, achieve fast transient transition, and significant enhance system reliability.