A surgical stapling device includes a housing and a plurality of cartridges that are coupled together to form a barrel that is rotatably supported within the housing. Each of the cartridges defines a plurality of staple pockets, each supporting a staple. An anvil is coupled to the housing and is movable in relation to the barrel between an open position and a clamped position. A guide shaft extends through the housing and through the barrel. The guide shaft supports a sled and a clamping member. The sled is configured to translate through the barrel to eject the staples from an active cartridge of the plurality of cartridges in response to actuation of a push rod. After firing staples from the active cartridge, the sled and the guide shaft are configured to index or rotate the barrel within the housing to move a second cartridge of the plurality of cartridges to the active position upon retraction and subsequent movement of the sled through a second firing stroke.