Liquid crystal display (LCD) systems and related methods with pixel elements driven at different frequencies are provided. A representative LCD system includes: a plurality of pixel elements arranged in an array, each of the plurality of pixel elements having a first sub-region and a second sub-region; a low-frequency driving circuit operative to drive each of the first sub-regions; and a high-frequency driving circuit operative to drive each of the second sub-regions at a driving frequency different than a driving frequency of the low-frequency driving circuits; wherein the first sub-regions exhibit a different size than the second sub-regions.