An method of driving an AMOLED is provided, including: dividing grayscale values of each pixel of each frame into N portions, so as to obtain N PWM driving signals of an organic light emitting diode; dividing the driving time of each frame of the organic light emitting diode into N sub-driving times, wherein one of the sub-driving times of each frame corresponds to one of the PWM driving signals; and transmitting all of the PWM driving signals of each frame to the organic light emitting diode at the corresponding sub-driving time, so as to drive and display an image.